The COVID-19 pandemic pushed the healthcare supply chain to the edge. Critical supply shortages have threatened the trust of clinicians and patients who depend on the availability of safe and reliable products, while exposing the vulnerabilities of supply chain practices that have sought to keep supply and operational costs as low as possible. Two esteemed members of Bellwether League’s Hall of Fame for Healthcare Supply Chain Leadership share their perspectives on how the lessons learned in the pandemic provide the foundation for advancing supply chain strategies, building critical capabilities, and achieving the level of supplier-provider partnerships that have been long sought but seldom achieved.